A computing microphotometer for cell analyses

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Abstract
A scanning and printing computing micro-photometer for analyses of large quantities of tissue cells and cell structures is described. One pertinent problem in quantitative cytology using microspectrography within some range of the spectrum, is the time it takes to obtain quantitative data on specific substances from many measurements on each cell and then to repeat them on many cells in order to get statistically significant results. Every problem on differentiation, cell growth or function involves this difficulty, when the specimen is a section through a number of cells. With the apparatus 12000 measurements can be made on an area 30 x 36 mm and the results are automatically computed and recorded in numbers point by point as they occur in the specimen. The area of the specimen covered by a single measurement is usually 3u 2 and an ultimate resolution of 1 [mu] is possible. Due to a special control system every detail within the microscopic image can be localized and measured separately.

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