Practical Synthesis of 1,1′-Binaphthyl-2-carboxylic Acids via Side Chain Oxidation of 2-Methyl-1,1′-binaphthyls
- 1 June 1986
- journal article
- research article
- Published by Oxford University Press (OUP) in Bulletin of the Chemical Society of Japan
- Vol. 59 (6) , 2044-2046
- https://doi.org/10.1246/bcsj.59.2044
Abstract
Four 1,1′-binaphthyl-2-carboxylic acids were obtained in 38–53% isolated yield via three-stage oxidation of 2-methyl-1,1′-binaphthyls, that is, i) NBS-bromination to benzylic bromides, ii) treatment with sodium salt of 2-nitropropane to aldehydes, and iii) KMnO4–oxidation to carboxylic acids.Keywords
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