Analysis by Immunoelectron Microscopy of Type-C Viruses Associated With Primary and Short-Term Transplanted Mouse Plasma Cell Tumors

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Abstract
Immunoelectron microscopy was applied to analysis of a) antigenic properties of type-C viruses and b) the appearance of differentiation antigen PC1 in primary and/or short-term transplanted mineral oil-induced myelomas of 4 mouse strains (BALB/c; 2 recombinant strains, C × BG and C × BJ; and C57BL/6). In PC+ strain BALB/c mice, primary myelomas whose cells carried PCl antigen produced many type-C viruses. These viruses were classified into 3 populations: murine myeloma-associated viruses (MuMAV) carrying a type-specific virus envelope antigen xVEA distinct from known typical murine leukemia virus (MuLV); MuLV (Gross); and other yet uncharacterized type-C viruses. In PC- strains, where normal plasma cells carried no PCl antigen, myeloma cells from some mice became PC+ and released complete type-C viruses, either xVEA+MuMAV alone or all 3 populations. However, some mice developed PC- myelomas accompanied by no viruses or only uncharacterized viruses. These results led to 2 possible conclusions: that PC1 antigen was perhaps induced by xVEA+ MuMAV; and that xVEA+MuMAV and/or the uncharacterized type-C viruses may have had an important role in the development of some myelomas. The finding of PC1 antigen on macrophages added new information on the tissue distribution of this antigen.

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