Carcinogenicity Test of Acetoxime in MRC-Wistar Rats23
- 1 October 1982
- journal article
- research article
- Published by Oxford University Press (OUP) in JNCI Journal of the National Cancer Institute
- Vol. 69 (4) , 961-962
- https://doi.org/10.1093/jnci/69.4.961
Abstract
Acetoxime was tested for carcinogenicity by chronic administration in the drinking water to male and female outbred MRC-Wistar rats. The dose of 1.0 g/Iiter was administered 5 days/week for 18 months (total dose, 6.2–7.0 g/rat). The test compound induced benign hepatocellular adenomas in 80% of the males but did not produce tumors in the females. This is the first report that oximes, which are fairly widely used in industry, are tumorigenic.Keywords
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