FolM, A New Chromosomally Encoded Dihydrofolate Reductase in Escherichia coli
- 1 December 2003
- journal article
- research article
- Published by American Society for Microbiology in Journal of Bacteriology
- Vol. 185 (23) , 7015-8
- https://doi.org/10.1128/jb.185.23.7015-7018.2003
Abstract
Escherichia coli (thyA DeltafolA) mutants are viable and can grow in minimal medium when supplemented with thymidine alone. Here we present evidence from in vivo and in vitro studies that the ydgB gene determines an alternative dihydrofolate reductase that is related to the trypanosomatid pteridine reductases. We propose to rename this gene folM.Keywords
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