Experimental Corneal Calcification

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Abstract
Experimental corneal calcification was induced in rabbits by peroral feeding with dihydrotachysterol and by perfusion of the anterior chamber of the eye with a diluted solution of permanganate. The beginning of calcification was studied with an electron microscope. The presence of round-shaped structures was observed on the third day following the initial treatment. They were localized mostly beneath the basal membrane of the corneal epithelium, but some of them were also situated on the anterior surface of the basal membrane and in deeper layers of the corneal stroma. Their ultrastructure was of low electron density. In the calcified areas, the periphery of these structures was covered with clusters of needle-like crystals. The paper discusses the current views on the initial sites of calcification and the presence of globular round-shaped structures found mostly on the boundary between the corneal epithelium and stroma.

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