THE ANALEPTIC EFFECTS OF DOXAPRAM HYDROCHLORIDE ON THIOPENTONE INDUCED DEPRESSION

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Abstract
A study of the analeptic properties of doxapram hydrochloride, as judged by its effects on the depression induced by moderate doses of thiopentone, was carried out in sixty patients. Three dose levels of the drug were employed, all of which produced marked increases in alveolar ventilation. These increases were due almost entirely to effects on tidal volume. Although the initial peak of stimulation was transient, following this peak, alveolar ventilation never fell below prethiopentone control values. An increase in the level of consciousness was also seen at each dose level. The largest dose used was 1 mg/kg and the greatest effects in terms of magnitude and duration were seen with this dose. No significant effects on blood pressure or pulse rate or side effects such as coughing, sneezing, laryngospasm or increased muscle tone were seen.

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