The synthesis of the epoxide and some other possible metabolites of precocene I
- 1 January 1984
- journal article
- research article
- Published by Royal Society of Chemistry (RSC) in Journal of the Chemical Society, Perkin Transactions 1
- No. 8,p. 1733-1738
- https://doi.org/10.1039/p19840001733
Abstract
The synthesis of precocene I epoxide, 3,4-epoxy-7-methoxy-2,2-dimethylchroman (8), is described. This compound is the highly reactive metabolite responsible for the biological effects of the precocenes. The syntheses of some other oxygenated derivatives of precocene I, which are themselves possible metabolites, are also described.This publication has 11 references indexed in Scilit:
- Metabolic fate of the hepatotoxic anti-juvenile hormone precocene II in the ratToxicology, 1982
- Analogues of antijuvenile hormonesJournal of the Chemical Society, Perkin Transactions 1, 1982
- Hepatotoxicity of the anti-juvenile hormone precocene II and the generation of dihydrodiol metabolitesChemico-Biological Interactions, 1981
- Enzymic Synthesis of Juvenile Hormone in Locust Corpora Allata: Evidence for a Microsomal Cytochrome P‐450 Linked Methyl Farnesoate EpoxidaseEuropean Journal of Biochemistry, 1981
- Precocene II Metabolism in Insects: Synthesis of Potential Metabolites and Identification of Initial in Vitro Biotransformation ProductsJournal of Agricultural and Food Chemistry, 1980
- Precocene II metabolism: Comparative in vivo studies among several species of insects, and structure elucidation of two major metabolitesPesticide Biochemistry and Physiology, 1980
- Lethal metabolism of precocene-I to a reactive epoxide by locust corpora allataNature, 1980
- Radiosynthesis and metabolism of the insect antijuvenile hormone, precocene IIJournal of Agricultural and Food Chemistry, 1977
- Precocene-induced degeneration of the corpus allatum of adult females of the bug Oncopeltus fasciatusJournal of Insect Physiology, 1977
- Discovery of Insect Anti-Juvenile Hormones in PlantsScience, 1976