Comparative localization of neurons containing ovine corticotropin releasing factor (CRF)‐like and neurophysin‐like immunoreactivity in the diencephalon of the pigeon (Columba livia domestica)

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Abstract
Neural elements immunoreactive for ovine corticotropin releasing factor‐like immunoreactivity(oCRF‐LI) were shown to be present in the diencephalon of the pigeon by using peroxidase‐antiperoxidase immunocytochemistry. The external zone of the anterior median eminence contains a rich network of varicose oCRF‐LI fibers in close proximity to the pituitary portal capillaries. Perikarya reactive for oCRF‐LI were found in several regions known to innervate the median eminence and gave rise to axons which joined the hypothalamo‐hypophyseal tract. A close topographical relationship between neurophysin‐containing and oCRF‐LI‐containing neurons was found in anterior periventricular regions. These observations suggest that oCRF‐LI material might be involved in the hypothalmic control of anterior pituitary hormone secretion in birds, and that neurophysin‐ and oCRF‐LI‐producing nerve cells might be functionally coupled.