Activity of Megazol, a Trypanocidal Nitroimidazole, Is Associated with DNA Damage
Open Access
- 1 October 2003
- journal article
- Published by American Society for Microbiology in Antimicrobial Agents and Chemotherapy
- Vol. 47 (10) , 3368-3370
- https://doi.org/10.1128/aac.47.10.3368-3370.2003
Abstract
DNA damage associated with the trypanocidal activity of megazol [2-amino-5-(1-methyl-5-nitro-2-imidazolyl)-1,3,4-thiadiazole] was shown in experiments in which DNA repair-deficient RAD51−/− Trypanosoma brucei mutants were found to be hypersensitive to the drug. Parasites resistant to megazol were selected and showed modest cross-resistance to other trypanocides, although neither drug efflux nor changes to intracellular thiols correlated with resistance.Keywords
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