Synthesis of an Oligonucleotide Bearing a Phosphate Function at the 5′-Terminus Using a Novel Protecting Group in Terms of a Cellulose Acetate Derivative as a Polymer-Support
- 1 December 1993
- journal article
- research article
- Published by Taylor & Francis in Nucleosides and Nucleotides
- Vol. 12 (10) , 1015-1032
- https://doi.org/10.1080/07328319308016201
Abstract
Synthesis of the title oligonucleotide bearing a phosphate function at the 5′-terminus, i.e., pCpUpCpGpUpCpCpApCpCpA, by the use of the terminal cytidylic acid unit involving a novel protecting group of 2-[2-(monomethoxytrityloxy)ethylthio]ethyl group on its 5′-phosphoryl function in terms of a cellulose acetate polymer-support is described.Keywords
This publication has 15 references indexed in Scilit:
- Solid Supported Chemical 5′-Phosphorylation of Oligodeoxy-Ribonucleotides that can be Monitored by Trityl Cation Releasi Application to Gene SynthesisNucleosides and Nucleotides, 1987
- Solid phase 5′-phosphorylation of oligonucleotidesTetrahedron Letters, 1987
- Chemical 5′-phosphorylation of oligonucleotidesvaluable in automated DNA synthesisTetrahedron Letters, 1986
- Fluorescence detection in automated DNA sequence analysisNature, 1986
- Synthesis and properties of 2',5'-adenylate trimers bearing 2'-terminal 8-bromo- or 8-hydroxyadenosine.CHEMICAL & PHARMACEUTICAL BULLETIN, 1986
- Synthesis of spin‐labelled di‐ and tri‐2‐deoxyadenylatesRecueil des Travaux Chimiques des Pays-Bas, 1986
- Synthesis and hybridization of dodecadeoxyribonucleotides containing a fluorescent pyridopyrimidine deoxynucleosideNucleic Acids Research, 1985
- Arylsulfonyl chlorides in the presence of N-methylimidazole as efficient condensing reagents in phosphotriester oligonucleotide synthesisTetrahedron Letters, 1982
- Arylsulfonyltetrazoles, new coupling reagents and further improvements in the triester method for the synthesis of deoxyribooligonucleotides1Nucleic Acids Research, 1977
- New general method for the synthesis of phosphate-protected deoxyribooligonucleotides. IVJournal of the American Chemical Society, 1972