CORTISOL-4-C14IN THE ADRENAL OF THE NORMAL AND VITAMIN C DEFICIENT GUINEA PIG1

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Abstract
Metabolism of cortisol-4-C14 has been studied in normal and in vitamin C deficient guinea pigs. Cortisol-4-C14 and its metabolites were found in the adrenal gland after the intravenous injection of labeled cortisol. Compared to normal animals, guinea pigs that have been on ascorbic acid deficient diet for 7 or 14 days showed a more rapid loss of the labeled material from the adrenal gland. This rapid disappearance was unique for the adrenal gland and was not observed in plasma, liver, kidney, spleen, and thymus of vitamin C deficient animals. This finding supports the idea that vitamin C may effect synthesis, exchange, and release of cortisol in the adrenal cortex.