EFFECTS OF THYROID FEEDING, THYROIDECTOMY AND ADRENALECTOMY ON THIOUREA INTOXICATION IN RATS

Abstract
Thiourea admn. to rats often causes a severe intoxication in which the most prominent anatomical findings are pulmonary congestion and edema, and pleural effusion. This intoxication is more severe in [male] than in [female] rats. Older rats are more affected than young ones. Thyroid feeding greatly increases the incidence of the intoxication, the severity and rapidity of onset of symptoms and death in both sexes, while thyroidectomy decreases all these. Adrenalectomy does not increase the incidence of thiourea intoxication.

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