The effects of capsaicin on intestinal sodium and fluid transport.

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Abstract
Capsaicin, the pungent component of red pepper, was studied to determine its inhibitory effect on fluid and Na+ absorption using rat and hamster everted jejunal sacs. At a mucosal concentration of 14.0 mg% incubated for 60 min, capsaicin reduced the fluid transport into the serosal side by 14.8% in rat and 23.9% in hamster. Similarly, Na+ transport was also inhibited by 12.5% and 26.2% in rat and hamster, respectively. Such decrease in serosal Na coincided with the increase in Na+ content of the gut wall and the intracellular Na+ concentration in the epithelial layer. It is, accordingly, concluded that capsaicin inhibits the Na+ exit through the serosal pole of the epithelium. These observations may provide an explanation for the previously observed inhibition of glucose transport.

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