Myocardial Necrosis in the Rat: a Comparison between Isoprenaline, Orciprenaline, Salbutamol and Terbutaline

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Abstract
The cardiotoxic effects of isoprenaline, orciprenaline, salbutamol, and terbutaline were compared in rats following daily subcutaneous administration for three consecutive days. Isoprenaline appeared to be the drug prone to induce myocardial necrosis, and salbutamol and terbutaline the least likely to do so. The data suggest that the more β1-stimulating a compound is, the more likely it is to causemyocardial necrosis.