An investigation of the activities of 3-hydroxykynureninase and kynurenine aminotransferase in the brain in Huntington's disease
- 1 February 1995
- journal article
- Published by Springer Nature in Journal Of Neural Transmission-Parkinsons Disease and Dementia Section
- Vol. 102 (1) , 67-73
- https://doi.org/10.1007/bf01276566
Abstract
Previous reports have indicated abnormalities in the concentrations of metabolites of the tryptophan/kynurenine pathway in the brain in Huntington's disease. These have included an increase in 3-hydroxykynurenine and both increases and decreases in kynurenic acid. The activities of two enzymes involved in the metabolism of these compounds, 3-hydroxykynureninase and kynurenine aminotransferase, have been determined in post mortem brain tissue taken from Huntington's disease patients and control subjects.Keywords
This publication has 28 references indexed in Scilit:
- Increased Concentrations of the Neurotoxin 3‐Hydroxykynurenine in the Frontal Cortex of HIV‐1‐Positive PatientsJournal of Neurochemistry, 1995
- QUINOLINIC ACID AND KYNURENINE PATHWAY METABOLISM IN INFLAMMATORY AND NON-INFLAMMATORY NEUROLOGICAL DISEASEBrain, 1992
- Does impairment of energy metabolism result in excitotoxic neuronal death in neurodegenerative illnesses?Annals of Neurology, 1992
- Excitatory amino acid binding sites in the caudate nucleus and frontal cortex of huntington's diseaseAnnals of Neurology, 1991
- Measurement of Rat Brain Kynurenine Aminotransferase at Physiological Kynurenine ConcentrationsJournal of Neurochemistry, 1991
- The role of hydrogen peroxide in the in vitro cytotoxicity of 3-hydroxykynurenineNeurochemical Research, 1990
- Kynurenine Pathway Measurements in Huntington's Disease Striatum: Evidence for Reduced Formation of Kynurenic AcidJournal of Neurochemistry, 1990
- Increase in Kynurenic Acid in Huntington's Disease Motor CortexJournal of Neurochemistry, 1989
- Brain Quinolinic Acid in Huntington's DiseaseJournal of Neurochemistry, 1988
- Kynurenines and SeizuresEpilepsia, 1981