Regenerating skeletal muscle contains transferrin and a transferrin-dependent growth factor

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Abstract
The myogenic growth-stimulating activity in chicken breast muscle during regeneration following cold injury has been studied. Muscle extracts prepared at various stages of generation were added to the culture medium and [3H]thymidine incorporation in intact chicken breast muscle cells in culture was measured. The extract of muscles on days 2-6 of regeneration contained a growth-stimulating factor identified as transferrin (Tf). The occurrence of an additional growth-stimulating factor (or factors) which required the presence of Tf was suggested in extracts of muscles on days 2-4 of regeneration. Tf and a Tf-dependent growth factor (or factors) may play important roles for the initiation of muscle regeneration in situ.