Reproducible effects of intravenously administered fish oil in acute relapsing psoriasis
- 1 January 1996
- journal article
- research article
- Published by Taylor & Francis in Journal of Dermatological Treatment
- Vol. 7 (4) , 211-214
- https://doi.org/10.3109/09546639609089550
Abstract
In several studies, dietary fish oil has been found to be beneficial in psoriasis, although the results have been controversial. To overcome the slow kinetics and limited availability of oral supplementation, a patient with acute relapsing psoriasis received an ω-3 fatty acid-based lipid emulsion (100 ml/day containing 2.1 g eicosapentaenoic acid (EPA) and 2.1 g docosahexaenoic acid) for 10 days. Clinical symptoms were assessed using the PASI. The PASI score dropped from 18.4 to 4.2. In addition leukotriene generation of ionophore-stimulated neutrophils showed a more than tenfold increase in EPA-derived lipoxygenase product formation. Because of a renewed exacerbation 1 year later, a second trial was started with double the previous dose over a period of 15 days. Probably because of a worse clinical condition, the patient responded more slowly than during the first trial, and the increase in EPA-derived metabolites was more retarded. Modulation of eicosanoid metabolism by intravenous ω-3 fatty acid supplementation appears to have a rapid and reproducible beneficial effect on inflammatory skin lesions in acute relapsing psoriasis.Keywords
This publication has 15 references indexed in Scilit:
- EEMCO guidance for the assessment of dry skin (xerosis) and ichthyosis: evaluation by stratum corneum shippingsSkin Research and Technology, 1996
- Surfactant-induced dermatitis: Comparison of corneosurfametry with predictive testing on human and reconstructed skinJournal of the American Academy of Dermatology, 1995
- Comparison of in vitro predictive tests for irritation induced by anionic surfactantsContact Dermatitis, 1995
- Lipid mediators, free fatty acids and psoriasisProstaglandins, Leukotrienes & Essential Fatty Acids, 1995
- Corneosurfametry: A Predictive Assessment of the Interaction of Personal-Care Cleansing Products with Human Stratum corneumDermatology, 1994
- Exploration of a quantitative dansyl chloride technique for measurement of the rate of desquamationClinical and Experimental Dermatology, 1987
- The conversion of dietary eicosapentaenoic acid to prostanoids and leukotrienes in manProgress in Lipid Research, 1986
- Alterations in human leukocyte function induced by ingestion of eicosapentaenoic acidJournal of Clinical Immunology, 1986
- Drugs which influence the stratum corneum and techniques for their evaluation*Clinical and Experimental Dermatology, 1981
- Increased concentrations of nonesterified arachidonic acid, 12L-hydroxy-5,8,10,14-eicosatetraenoic acid, prostaglandin E2, and prostaglandin F2alpha in epidermis of psoriasis.Proceedings of the National Academy of Sciences, 1975