Abstract
Data gathered during ecological studies on Eastern (EEE) and Western (WEE) equine encephalitis virus in Louisiana, New Jersey, Massachusetts and Alabama are presented. Virus isolation and serum neutralization tests on wild birds indicate two differing patterns of the activity of EEE virus. One pattern seems to represent normal endemic activity of the virus and is associated with little or no clinical disease in man or domestic animals. In the second, the virus spreads among wild birds much more rapidly and appears outside of its usual geographic limits and species range. The second pattern is regularly associated with clinical disease in man and domestic animals. An under-standing of the ecological factors which control the activity of this virus may allow the prediction or early detection of epidemics and prevent the involvement of man or domestic animals.

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