A macrolide 3-O-acyltransferase gene from the midecamycin-producing species Streptomyces mycarofaciens
Open Access
- 1 August 1992
- journal article
- Published by American Society for Microbiology in Journal of Bacteriology
- Vol. 174 (15) , 5141-5144
- https://doi.org/10.1128/jb.174.15.5141-5144.1992
Abstract
The Streptomyces mycarofaciens mdmB gene encodes a 3-O-acyltransferase that catalyzes the addition of acetyl and propionyl groups to position 3 of the lactone ring in 16-member macrolide antibiotics like midecamycin and spiramycin. A putative O-methyltransferase gene (mdmC) is immediately downstream of mdmB, and both of these genes are closely linked to the mdmA midecamycin resistance gene.Keywords
This publication has 15 references indexed in Scilit:
- Cloning and sequence analysis of genes involved in erythromycin biosynthesis in Saccharopolyspora erythraea: sequence similarities between EryG and a family of S-adenosylmethionine-dependent methyltransferasesMolecular Genetics and Genomics, 1991
- Molecular characterization of the O‐acetyl transferase gene of converting bacteriophage SF6 that adds group antigen 6 to Shigella flexneriMolecular Microbiology, 1991
- Molecular cloning and characterization of rat liver catechol-O-methyltransferaseGene, 1990
- Production of a hybrid macrolide antibiotic in Streptomyces ambofaciens and Streptomyces lividans by introduction of a cloned carbomycin biosynthetic gene from Streptomyces thermotoleransGene, 1989
- The impact of genetic engineering on the commercial production of antibiotics byStreptomyces and related bacteriaApplied Biochemistry and Biotechnology, 1987
- [9] Plasmid and phage vectors for gene cloning and analysis in StreptomycesPublished by Elsevier ,1987
- Plasmids, Recombination and Chromosome Mapping in Streptomyces lividans 66Microbiology, 1983
- Gene expression in Streptomyces: Construction and application of promoter-probe plasmid vectors in Streptomyces lividansMolecular Genetics and Genomics, 1982
- A simple method for displaying the hydropathic character of a proteinJournal of Molecular Biology, 1982
- A general method applicable to the search for similarities in the amino acid sequence of two proteinsJournal of Molecular Biology, 1970