Ribostamycin production by a mutant of butirosin producing bacteria.
- 1 January 1978
- journal article
- research article
- Published by Japan Antibiotics Research Association in The Journal of Antibiotics
- Vol. 31 (10) , 966-969
- https://doi.org/10.7164/antibiotics.31.966
Abstract
By the use of an improved colony selection technique, xylostasin and ribostamycin producing mutants were isolated from nitrosoguanidine treated Bacillus circulans B15M, a producer of butirosins A and B. Among these structurally related aminoglycosides, ribostamycin is the well-known product of a Streptomyces and was not isolated as a bacterial metabolite. A selected mutant of strain 306, which produces xylostasin and ribostamycin, was further mutagenized in expectation of getting an improved strain having the ability to accumulate a large amount of ribostamycin in the culture broth. One mutant, strain 451, derived from strain 306, produced ribostamycin free of xylostasin.This publication has 1 reference indexed in Scilit:
- An approach to the biosynthetic pathway of butirosins and the related antibiotics.The Journal of Antibiotics, 1978