SYNAPTOSOMAL TRANSPORT: A CHLORIDE DEPENDENCE FOR CHOLINE, GABA, GLYCINE AND SEVERAL OTHER COMPOUNDS

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Abstract
Abstract— The synaptosomal transport of fourteen different neurotransmitters, neurotransmitter precursors and other amino acids was tested for a chloride dependence. Those compounds having sodium‐dependent‘high‐affinity’transport systems exhibited a chloride dependence which was maintained over time and which was concentration dependent. Low chloride concentrations altered the transport kinetics of the compounds examined. The reduced accumulation of these compounds in chloride deficient media was not due to increased efflux or alterations in metabolism. The significance of these results for models of transport, methods in transport studies and for other factors are discussed.