Noninvasive Method for Determination of Propylene Carbonate in Pharmaceutical Formulations Using Fourier Transform-Infrared Spectrometry
- 1 January 1987
- journal article
- research article
- Published by Taylor & Francis in Spectroscopy Letters
- Vol. 20 (8) , 619-631
- https://doi.org/10.1080/00387018708082284
Abstract
A noninvasive stability-indicating assay method utilizing Fourier Transform-Infrared/Attenuated Total Reflectance (FT-IR/ATR) Spectrometry for the determination of propylene carbonate in pharmaceutical formulations is described. The linearity of propylene carbonate response was studied by use of its carbonyl stretching frequency after spectral subtractions were performed to remove interfering bands. Analyses were performed on aqueous solutions of propylene carbonate, an aqueous cream formulation, and an anhydrous ointment spiked with propylene carbonate.Keywords
This publication has 3 references indexed in Scilit:
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- Spectroscopic study of the interconversion of chemisorbed surface species: The reaction RhI(CO)2 + CO $rarr; Rh1(CO)3Journal of Catalysis, 1984
- Analysis and distillation of propylene carbonateAnalytical Chemistry, 1967