Topical methoxsalen and blacklight in the treatment of psoriasis

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Abstract
Patients (30) with recalcitrant psoriasis were treated with topical methoxsalen and blacklight (UVA). A 1% concentration either in an acetone, alcohol, propylene glycol vehicle, or hydrophilic ointment, USP, applied 2 h before light exposure was highly effective. Twelve patients were completely cleared and 9 were markedly improved in 3-5 wk. Plaque-type and guttate psoriasis responded best while exfoliative psoriasis benefitted less. Maintenance of a phototoxic reaction in the lesion was necessary for total resolution. Topical methoxsalen and blacklight is feasible for outpatient treatment of plaque-type psoriasis of limited extent.