Importance of the Spleen for the Immuno-Inhibitory Action of Linoleic Acid in Mice
- 1 January 1977
- journal article
- research article
- Published by S. Karger AG in International Archives of Allergy and Immunology
- Vol. 53 (5) , 469-473
- https://doi.org/10.1159/000231785
Abstract
Certain immuno-inhibitory effects of a polyunsaturated fatty acid, linoleic acid (C18:2), no longer occur after splenectomy of young adult CBA mice. This observation suggests that the spleen is a major intermediary in the action of C18:2 on the lymphoreticular system. Pathways of this action remain to be elucidated. Possibilities include C18:2-stimulated suppressor cell generation in the spleen, or excess biosynthesis of immuno-inhibitory prostaglandins by splenic macrophages.Keywords
This publication has 2 references indexed in Scilit:
- Influence of polyunsaturated fatty acids on survival of skin allografts and tumor incidence in mice.Proceedings of the National Academy of Sciences, 1976
- The Mechanism of Immunoinhibition by Arachidonic and Linoleic Acid: Effects on the Lymphoid and Reticulo-Endothelial SystemsInternational Archives of Allergy and Immunology, 1976