Sensitivity of bovid herpesvirus 2 replication to temperatures found in the natural host

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Abstract
Two isolates of bovid herpesvirus 2 replicated poorly in bovine testicular cells and fetal kidney cells at 39–40° C, temperatures commonly observed in virus-infected cattle. High viral titers occurred in replicate cultures at 30–37° C. Persistent viral infections were noted in cultures maintained at 40° C. Interferon-like activity was not responsible for the high-temperature restriction since the level was not significantly different between virus-infected cultures incubated at 35° or 40° C. Spontaneous viral inactivation was only three times as rapid at 41° as at 35° C. Analysis of temperature shift experiments with respect to results of growth studies and electron microscopy indicated a temperature sensitive event late in replication. The sensitiv of bovid herpesvirus 2 replication to elevated temperature provides a possible explanation for the extensive viral growth and occasionally severe lesions which are limited exclusively to the skin of infected cattle.