Suppression of 17-Hydroxycorticosteroids in Plasma and Urine by Single and Divided Doses of Triamcinolone

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Abstract
PROLONGED suppression of the pituitary-adrenal axis after therapy with anti-inflammatory steroids, with resultant decrease in adrenocortical secretion and impaired response to stress, has been the subject of numerous published articles.1 2 3 Di-Raimondo and Forsham,4 , 5 however, reported that less suppression occurs when the total dose of corticosteroid is administered in the morning.In this study we compared the extent and duration of suppression of adrenocortical secretion by 8 mg. of triamcinolone given as a single dose in the morning and by the same amount given in 4 divided doses throughout the day.Materials and MethodsIn a pilot study daily morning doses . . .