4-Amino Pteroylglutamic Acid (Aminopterin), Pteroylglutamic (Folic) Acid, and Response of Frogs, Rana clamitans, to Estrogens.

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Abstract
4-Aminopteroylglutamic acid (aminopterin) markedly decreases, whereas folic acid increases, the response of the oviducts of newly metamorphosed female frogs (Rana clami-tans) to estradiol. The aminopterin effect could not be reversed by folic acid in ratios as high as 100:1 of folic acid to aminopterin.