Mouse Bone-marrow Response to Low Doses of Whole-body Gamma Irradiation: Induction of Micronuclei
- 1 January 1990
- journal article
- research article
- Published by Taylor & Francis in International Journal of Radiation Biology
- Vol. 57 (1) , 97-101
- https://doi.org/10.1080/09553009014550371
Abstract
The induction of micronuclei in mouse bone marrow was studied after whole-body exposure to low doses of gamma radiation, ranging from 5 to 75 cGy. Micronuclei were scored at 10 and 30 h after irradiation. A linear dose response was obtained at both postirradiation times. However, the number of micronuclei per 100 nuclei was lower at 30 h than at 10 h, and the dose—response curve for the former had a shallower slope. When fitted to the αD + βD2 model, a negative β value was obtained. This could be due to division delay, combined with elimination of damaged cells by death at higher doses.This publication has 8 references indexed in Scilit:
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