BONE MARROW TRANSPLANTATION AFTER LETHAL CHEMOTHERAPY IN “NUDE” MICE1
- 1 September 1977
- journal article
- research article
- Published by Wolters Kluwer Health in Transplantation
- Vol. 24 (3) , 218-222
- https://doi.org/10.1097/00007890-197709000-00007
Abstract
Isogeneic bone marrow transplantation was performed in nude and normal C3H mice after lethal doses of dimethylmyleran (DMM), meso-DMM and (.+-.)-DMM were given. Nude mice were not more sensitive to DMM or its isomers than normal mice. With adequate cell doses in the range of 3 .times. 106 to 30 .times. 106 bone marrow cells or 10 .times. 106 to 30 .times. 106 spleen cells, the survival rate after lethal chemotherapy was not significantly different between nude mice reconstituted with a graft from nude donors and normal mice reconstituted with a graft from normal donors. Only with suboptimal cell doses (1 .times. 106 bone marrow cells) was survival superior in normal mice. The hemopoietic capacity was not conferred to the nude donor cells by an extrinsic factor. Nude mice accepted bone marrow grafts from allogeneic nude donors.This publication has 3 references indexed in Scilit:
- Reconstitution Capacity of Bone Marrow Cells from Nude Mice in Radiation ChimerasActa Haematologica, 1976
- CHEMICAL AND BIOLOGICAL PROPERTIES OF BUSULFAN (MYLERAN)1974
- Wiederherstellung der Hämatopoese nach letaler Dosis von Dimethyl-Myleran durch isologe Knochenmarktransplantation bei Mäusen. Versuche zur Beeinflussung der Intoleranz gegenüber homologem Knochenmark durch 6-Mercaptopurin, Aminochlorambucil und CortisonActa Haematologica, 1961