Nuclear Protein Matrix: Association with Newly Synthesized DNA
- 25 July 1975
- journal article
- Published by American Association for the Advancement of Science (AAAS) in Science
- Vol. 189 (4199) , 291-293
- https://doi.org/10.1126/science.1145202
Abstract
The residual structural framework of the cell nucleus termed the nuclear protein matrix, is associated with newly synthesized DNA in regenerating rat liver. One minute after rats are injected with [3-H] thymidine, more than 90 percent of the total tritium in nuclear DNA is associated with the matrix DNA although this DNA comprises only 25 percent of the total nuclear DNA. In contrast, the bulk DNA, 75 percent of total nuclear DNA, contains less than 8 percent of the total labeled DNA. The percentage of total labeled DNA associated with the bulk DNA increases for 30 minutes after injection and decreases correspondingly in the matrix DNA.Keywords
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