Chemical and Genetic Characterization of a Monoclonal IgA(λ) Protein with Both Cryo‐ and Pyro‐Precipitability

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Abstract
Studies of a monoclonal IgA(λ) protein with both cryo‐ and pyro‐precipitability show that it belongs to the IgA2 subclass and is positive for the A2m(2) allotypic marker. Like other cryoglobulins, this protein also has an unblocked light chain, and its heavy chain belongs to the VHI subgroup. The first 22 N‐terminal amino acids of the λ chain of this protein showed less than 65% homology with those of other human λ chains but showed 86% identity with that of an amyloid fibril protein reported by others. The α chain of this protein appears to have more glutamic acid or glutamine, or both, and less isoleucine residues than other human α chains.