The Synthesis of (±)-Cordrastine. A New Route to the Phthalideisoquinoline System
- 1 October 1973
- journal article
- Published by Canadian Science Publishing in Canadian Journal of Chemistry
- Vol. 51 (19) , 3287-3293
- https://doi.org/10.1139/v73-490
Abstract
The phthalideisoquinoline system has been synthesized from substituted 2-phenyl-1,3-indandiones as starting materials. The key step in the synthesis is the rearrangement of the spirobenzylisoquinoline ring system to the phthalideisoquinoline system. The diastereomeric cordrastines, I and II, have been synthesized by this method and their relative configurations have been established by comparison of their p.m.r. spectra with those of phthalideisoquinoline alkaloids of known configuration.Keywords
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