Influence of the major histocompatibility complex on the repertoire of allospecific cytolytic T lymphocytes.

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Abstract
Superimposed on the heterogeneous anti-H-2Kb cytolytic T lymphocyte (CTL) receptor repertoire of allogeneic murine strains are reactivities that recur with high frequency among individuals of any given strain. These receptor specificities represent phenotypic markers of the CTL repertoire and were used to compare receptor repertoires of genetically disparate strains. Congenic strains differing only in the major histocompatibility complex (MHC) (B10.D2 and B10.BR) differ significantly in their H-2Kb-specific CTL repertoires. A role for the MHC in determination of the CTL precursor repertoire is demonstrated. The mechanism by which MHC influences CTL specificity was explored through analysis of the anti-H-2Kb repertoire of (B10.BR .times. B10.D2)F1 hybrids. Because at least 1 recurrent parental specificity was found to be recurrent in F1 progeny as well, MHC-specific tolerance apparently cannot be solely responsible for repertoire differences between MHC-disparate strains. The F1 repertoire is characterized by the emergence of several nonparental recurrent specificities.

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