Isolation and Properties of Metronidazole-Resistant Mutants of Bacteroides fragilis
Open Access
- 1 July 1979
- journal article
- research article
- Published by American Society for Microbiology in Antimicrobial Agents and Chemotherapy
- Vol. 16 (1) , 19-27
- https://doi.org/10.1128/aac.16.1.19
Abstract
Metronidazole-resistant mutants of Bacteroides fragilis , isolated after mutagenesis, had diminished ability to take up and metabolize the drug. All the metronidazole-resistant strains had depressed levels of pyruvate dehydrogenase compared with parent cultures. Their end products of glucose metabolism also differed from normal B. fragilis products and were consistent with deficiencies in pyruvate dehydrogenase activity.This publication has 15 references indexed in Scilit:
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