CYCLOPHOSPHAMIDE (CY) FACILITATED ADOPTIVE IMMUNOTHERAPY OF A CY-RESISTANT TUMOR - EVIDENCE THAT CY PERMITS THE EXPRESSION OF ADOPTIVE T-CELL MEDIATED IMMUNITY BY REMOVING SUPPRESSOR T-CELLS RATHER THAN BY REDUCING TUMOR BURDEN

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  • 1 September 1988
    • journal article
    • research article
    • Vol. 65  (1) , 87-92
Abstract
A cyclophosphamide (Cy)-resistant immunogenic tumour, the L5178Y lymphoma, was used to demonstrate that Cy-treatment of a host bearing this tumour enables passively transferred tumour-sensitized T cells to cause tumour regression without any need for Cy to cause a a reduction in tumour burden. It was shown that whereas infusion of tumour-sensitized T cells from immune donors had very little effect on growth of the tumour, and whereas treatment with 150 mg/kg of Cy caused appreciable enhancement of tumour growth, combination therapy with Cy plus immune T cells caused complete tumour regression and resulted in long-term survival. Evidence that Cy treatment facilitated the expression of adoptive immunity against the L5178Y lymphoma by eliminating tumour-induced suppressor T cells consisted of the demonstration that tumour regression caused by combination treatment with Cy and immune T cells could be inhibited by infusing the recipient with Cy-sensitive, L3T4+ T cells from tumour-bearing but not from normal donors.

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