Four-amino acid segment in steroid 5 alpha-reductase 1 confers sensitivity to finasteride, a competitive inhibitor.

This publication has 18 references indexed in Scilit:

• Characterization and chromosomal mapping of a human steroid 5α-reductase gene and pseudogene and mapping of the mouse homologue
  Published by Elsevier ,2004
• [19] Rapid and efficient site-specific mutagenesis without phenotypic selection
  Published by Elsevier ,2004
• Genetic and pharmacological evidence for more than one human steroid 5 alpha-reductase.
  Journal of Clinical Investigation, 1992
• Deletion of steroid 5α-reductase 2 gene in male pseudohermaphroditism
  Nature, 1991
• 3-Phosphinic acid and 3-phosphonic acid steroids as inhibitors of steroid 5α-reductase: Species comparison and mechanistic studies
  Bioorganic Chemistry, 1991
• Structural and biochemical properties of cloned and expressed human and rat steroid 5 alpha-reductases.
  Proceedings of the National Academy of Sciences, 1990
• Inhibitors of steroid 5α-reductase in benign prostatic hyperplasia, male pattern baldness and acne
  Trends in Pharmacological Sciences, 1989
• Hormonal effects of an orally active 4‐azasteroid inhibitor of 5α‐reductase in humans
  The Prostate, 1989
• Domain map of the LDL receptor: Sequence homology with the epidermal growth factor precursor
  Cell, 1984
• The pathogenesis of benign prostatic hyperplasia
  The American Journal of Medicine, 1980