Synthesis and specific pressor activity of [1-aspartic acid, 5-valine, 9-serine]angiotensin I ("fowl and angiotensin I")
- 1 February 1977
- journal article
- research article
- Published by American Chemical Society (ACS) in Journal of Medicinal Chemistry
- Vol. 20 (2) , 315-316
- https://doi.org/10.1021/jm00212a029
Abstract
[Asp1,Val5,Ser9]angiotensin I was synthesized by Merrifield''s solid-phase procedure. The dansylated derivative of this angiotensin was cochromatographed on the TLC with the dansylated angiotensin decapeptide isolated from white leghorn fowl. Either angiotensin showed identical behavior. The per mole pressor activity of the synthetic decapeptide (in rats anesthetized with pentobarbital and treated with pentolinium) as compared to mammalian angiotensins, i.e., [Ile5]angiotensin I, [Val5]angiotensin, I [Ile5]angiotensin II and [Val5]angiotensin II, was 157, 181, 114 and 85%, respectively.This publication has 1 reference indexed in Scilit:
- Measurement of Renin Activity in Human PlasmaCirculation Research, 1965