THE ACTION OF SULPHANILAMIDE ON RABBITS' LENSES IN VITRO

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Abstract
The lenses were maintained in vitro by the per-fusion culture method of de Haan. A normal therapeutic conc. of sulfanilamide (20 mg. %) in the nutrient fluid did not affect the transparency of the lens, but 400 mg. % caused cataractous changes, more marked in the lens of the young rabbit than in that of the adult. The capsule of the lens was shown to be freely permeable to sulfanilamide. It is known that sulfanilamide inhibits the enzymic action of carbonic anhydrase, a substance which is in reduced conc. in cataractous lenses.

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