Peritoneal Transport of Vancomycin in 4 Patients Undergoing Continuous Ambulatory Peritoneal Dialysis
- 1 January 1982
- journal article
- research article
- Published by S. Karger AG in Nephron
- Vol. 31 (1) , 37-39
- https://doi.org/10.1159/000182611
Abstract
The pharmacokinetics of vancomycin have been studied in 4 chronic renal failure patients undergoing continuous ambulatory peritoneal dialysis. Patients received 1 g of vancomycin in 2 liters of dialysate during an initial phase, and serum and dialysate samples were collected for vancomycin determination. 54% of the amount introduced into the peritoneal cavity were absorbed systemically during a 6-hour cycle. Peak serum concentrations averaged 23.7 µg/ml. Mean elimination half-life was calculated to be 66.9 h, and dialysis clearance averaged 2.4 ml/min.Keywords
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