Comparison of Natural and Synthetic Prostaglandins on Gastric and Pancreatic Secretions and Peptic Ulcer Formation in Conscious Cats
- 1 January 1976
- journal article
- research article
- Published by S. Karger AG in Digestion
- Vol. 14 (1) , 44-61
- https://doi.org/10.1159/000197798
Abstract
In conscious cats with chronic gastric and pancreatic fistulas, the natural prostaglandins (PGs) of the E (PGE1 and PGE2) and F (PGF1α and PGF2α) series and synthetic 15-methyl analog of PGE2, 15(S) 15-methyl-PGE2methylester were compared with regard to their action on gastric and pancreatic secretions and peptic ulcer formation. This study indicates that in comparison with natural PGs, the synthetic 15-methyl analog of PGE2 is a more potent inhibitor of gastric secretion regardless of the route of administration and the mode of gastric stimulation. It more effectively prevents the formation of peptic ulcers in conscious cats.Keywords
This publication has 2 references indexed in Scilit:
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