Analgesic Use and Chronic Renal Disease

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Abstract
To examine the use of analgesics as a cause of chronic renal disease, we performed a multicenter case–control study of 554 adults with newly diagnosed kidney disease (serum creatinine, ≥130 μmol per liter [1.5 mg per deciliter]) and 516 matched control subjects selected randomly from the same area of North Carolina. Histories of use of analgesics (phenacetin, acetaminophen, and aspirin) were obtained by telephone interview with the patients or their proxies.