POSSIBLE ORGANOPHOSPHATE-INDUCED PARKINSONISM

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Abstract
The patient was a crop duster with numerous episodes of acute organophosphate [insecticide] intoxication and chronic organophosphate exposure. The etiology of parkinsonism is discussed in terms of a balance hypothesis between cholinergic and dopaminergic neurotransmission in the striatum. A possible relationship between chronic organophosphate exposure and alterations in central cholinergic or dopaminergic activity was suggested. Agricultural workers may be at risk for the late development of parkinsonism.

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