Thrombocytopenic Purpura with Histiocytosis of the Spleen

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Abstract
THE recent independent observation, by several of us, of peculiar histiocytosis of the spleens of patients with "idiopathic" thrombocytopenic purpura has prompted the collection and review of the material here presented. The 9 patients†† described have shown no consistent abnormality of other blood elements, and the unusual histiocytes appear limited to the spleen. Only 2 patients had onset of symptoms in middle life, as did 2 similar ones described in the literature.1 , 2 In the majority the symptoms developed in childhood or early adult life. Easy bruising, repeated epistaxis or formation of hematomas after injury tended to precede more severe manifestations. . . .

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