AN ALTERNATIVE MECHANISM FOR THE PROPERDIN SYSTEM
Open Access
- 1 October 1958
- journal article
- research article
- Published by Rockefeller University Press in The Journal of Experimental Medicine
- Vol. 108 (4) , 515-535
- https://doi.org/10.1084/jem.108.4.515
Abstract
Evidence is presented that phenomena ascribed to the properdin system may be explained in terms of classical antibody (Ab) in combination with three of the components of complement (C'), i.e., C'1, C'4, and C'2 respectively. The results suggest that the complex of properdin (P) with zymosan (Z) represents a mixture of Z·Ab, Z·Ab·C'1, 4, Z·Ab-C'1, 4, 2, and Z·Ab·C'1, 4, 2 in a decayed state.Keywords
This publication has 13 references indexed in Scilit:
- Studies on the mechanism of hemolysis by antibody and complement.1958
- The possible role of the properdin system in transplantable cancer; the effect of zymosan on transplantable human carcinoma.1956
- CROSS-REACTIONS OF ANTITYPHOID AND ANTIPARATYPHOID B HORSE SERA WITH VARIOUS POLYSACCHARIDESThe Journal of Experimental Medicine, 1956
- NEUTRALIZATION OF BACTERIOPHAGE BY THE PROPERDIN SYSTEMProceedings of the National Academy of Sciences, 1956
- ELEVATION OF PROPERDIN LEVELS IN MICE FOLLOWING ADMINISTRATION OF BACTERIAL LIPOPOLYSACCHARIDESThe Journal of Experimental Medicine, 1956
- THE PROPERDIN SYSTEM AND IMMUNITY. IV. THE HEMOLYSIS OF ERYTHROCYTES FROM PATIENTS WITH PAROXYSMAL NOCTURNAL HEMOGLOBINURIA 1Journal of Clinical Investigation, 1956
- The Properdin System and Immunity: I. Demonstration and Isolation of a New Serum Protein, Properdin, and Its Role in Immune PhenomenaScience, 1954
- KINETIC STUDIES ON IMMUNE HEMOLYSIS .6. RESOLUTION OF THE C'-Y REACTION STEP INTO 2 SUCCESSIVE PROCESSES INVOLVING C'-2 AND C'-31954
- KINETIC STUDIES ON IMMUNE HEMOLYSIS .5. FORMATION OF THE COMPLEX EAC'X AND ITS REACTION WITH C'Y1954
- KINETIC STUDIES ON IMMUNE HEMOLYSIS .7. DECAY OF EAC'1,4,2, FIXATION OF C'3 AND OTHER FACTORS INFLUENCING THE HEMOLYTIC ACTION OF COMPLEMENT1954