Glycerite of Hydrogen Peroxide

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Abstract
A modified Oxford cup method utilizing paraffined cylinders on pre-inoculated dextrose agar was used. Peroxide-glycerol solutions made from either urea peroxide (4%) or H2O2 (92%) showed a bacteriotoxic action against 6 Gram-positive and 4 Gram-negative organisms. A greater bactericidal effect was noted with Gram-positive than with Gram-negative bacteria. The presence of 8-hydroxyquinoline in the peroxide solution as an added stabilizer did not appear to improve significantly the bacteriotoxic action of the soln. in the absence of serum, but did appear to enhance the activity in the presence of 10% horse serum. In comparison with 12 mercurial solns., including tinctures and aqueous solns. of Merbromin, Mercurochrome, Merseptal, Merthiolate, Metaphen; tincture of Mercresin and glycerite of Merthiolate, the glycerol-peroxide solns. showed, in general, greater bacteriotoxic action on Gram-positive organisms than did the mercurial solns. The latter were, for the most part, more effective on Gram-negative bacteria, although in specific cases the peroxide-glycerol solutions were more efficacious than some of the mercurial solns., particularly where water was the principal solvent for the mercurial compound. The effect of the antiseptics on colony appearance and pigment production particularly of Aerobacter cloacae and Pseudomonas aeruginosa was noted.

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