Induction of the c- fos Oncogene by Thyrotropic Hormone in Rat Thyroid Cells in Culture
- 25 July 1986
- journal article
- research article
- Published by American Association for the Advancement of Science (AAAS) in Science
- Vol. 233 (4762) , 458-460
- https://doi.org/10.1126/science.3726540
Abstract
Rat thyroid cells in culture, rendered quiescent by hormone deprivation, can be stimulated to undergo DNA synthesis in the absence of serum by the addition of purified thyrotropin. The primary effect in response to thyrotropin action in thyroid cells is the induction of the c-fos oncogene, followed by c-myc expression. This suggests that thyrotropin acts as a competence growth factor.This publication has 23 references indexed in Scilit:
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