The Effects of Gonadectomy and Oestradiol-17j3 on Pituitary Responsiveness to LH-RH in the Adult Male Marmoset (Callithrix jacchus)

1 January 1979

journal article
research article
Published by S. Karger AG in Journal of Medical Primatology

Vol. 8 (3) , 155-166
https://doi.org/10.1159/000460192

Abstract

Exogenous luteinizing hormone-releasing hormone (LH-RH) administered in a wide range of doses (0.2-25 .mu.g) to intact male marmoset monkeys induced a marked increase in plasma luteinizing hormone (LH) concentrations. Maximum LH concentrations achieved after injection of LH-RH occurred progressively later as the dosage increased. Bilateral orchidectomy significantly enhanced pituitary responsiveness to a standard dose (2.0 .mu.g) of LH-RH, whereas the introduction of estradiol-17.beta. implants effectively inhibited the response. LH-RH-induced LH release after gonadectomy (with and without estradiol-17.beta. treatment) was similar in males and females. The use of marmosets for appropriate investigation into the physiological role of LH-RH in controlling LH secretion in primates is proposed.

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