Forskolin as a tool to study the β‐adrenergic receptor‐elicited, labeled protein secretion in rat lacrimal gland
- 7 March 1983
- journal article
- Published by Wiley in FEBS Letters
- Vol. 153 (1) , 21-24
- https://doi.org/10.1016/0014-5793(83)80111-2
Abstract
In rat lacrimal glands, Forskolin induces a dose-dependent [3H]protein release. This effect can be potentiated by papaverine. As for the other inducers whose effects on protein secretion are assumed to be cAMP-mediated, Forskolin secretion time course shows a latency. Isoproterenol decreases the Forskolin EC 5- at least 60--times. On the other hand, Forskolin enhances the efficacy of isoproterenol without affecting its potency. As a whole, the data collected show that isoproterenol-induced [3H]protein secretion in rat lacrimal glands involved adenylate cyclase activation by coupling with β-adrenergic receptors.Keywords
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