Two‐dimensional spectra of intact tissue: Homonuclear Hartmann‐Hahn spectroscopy provides increased sensitivity and information content as compared to COSY

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Abstract
Hartmann‐Hahn (HOH AHA) spectroscopy led to good definition of proton spin systems of metabolites such as lactate, (phospho) creatine, and carnosine from a 3‐g sample of excised frog gastrocnemius muscle in a 17‐min experiment. The sign of the HOHAHA cross‐peak intensity appears to provide additional information about interactions between metabolites and their protein binding sites. © 1990 Academic Press, Inc.